Iron-catalyzed annulations of 2-(2-alkynyl)phenoxy)-1-arylethanones leading to substituted naphthalen-1-ols.
نویسندگان
چکیده
A novel intramolecular annulation of 1-(2-alkynylphenoxy)propan-2-ones catalyzed by iron, an economical and environmentally-benign transition metal, has been developed; this new atom-economical route includes dual C-H functionalizations to construct the naphthalen-1-ol or anthracen-1-ol skeletons.
منابع مشابه
Alkynyl Thioethers in Gold‐Catalyzed Annulations To Form Oxazoles
Non-oxidative, regioselective, and convergent access to densely functionalized oxazoles is realized in a functional-group tolerant manner using alkynyl thioethers. Sulfur-terminated alkynes provide access to reactivity previously requiring strong donor-substituted alkynes such as ynamides. Sulfur does not act in an analogous donor fashion in this gold-catalyzed reaction, thus leading to complem...
متن کاملPlatinum-catalyzed multistep reactions of indoles with alkynyl alcohols.
PtCl2 effectively catalyzes the multistep reaction of N-methyl indole (1 a) with pent-3-yn-1-ol (2 a) in THF at room temperature for 2 h to give indole derivative 3 a, which contains a five-membered cyclic ether group at C3 in 93% yield. Under similar reaction conditions, various substituted N-methyl indoles 1 b-h and indole (1 i) reacted efficiently with 2 a to afford the corresponding indole ...
متن کاملOrganocatalytic hetero [4+2] cycloaddition reactions of 2-(1-alkynyl)-2-alkene-1-ones: metal-free access to highly substituted 4H-pyrans.
Highly substituted 4H-pyrans can be smoothly synthesized from readily available 2-(1-alkynyl)-2-alkene-1-ones by DBU- or n-Bu(3)P catalyzed hetero-[4+2] cycloaddition reactions, in which 2-(1-alkynyl)-2-alkene-1-ones act as both heterodiene and heterodinenophile.
متن کاملReduction of 2 , 2 , 2 - trichloro - 1 - arylethanones by RMgX : mechanistic investigation and the synthesis of substituted a , a - dichloroketones †
2,2,2-Trichloro-1-arylethanones undergo high yielding reductions to the corresponding 2,2-dichloro-1-arylethanones in the presence of RMgX. A single electron transfer mechanism for the reaction is proposed based on trapping experiments. Reaction of the intermediate enolates with a range of electrophiles is described, providing a convenient route to substituted a,a-dichloro-b-hydroxyketones and ...
متن کاملSynthesis of 2-Amino-5-aryl-5,6-dihydro-7-(naphthalen-2-yl) Quinazolin-4-ols
Quinazolines exhibit various biological activities. In the present investigation a series of new 2-amino-5-aryl5,6-dihydro7-(naphthalen-2-yl)quinazolin-4-ols are synthesized by the condensation of various naphthyl substituted cyclohexenones with guanidine in presence of NaOEt. All the synthesized compounds are characterized by various spectral techniques.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical communications
دوره 35 شماره
صفحات -
تاریخ انتشار 2009